MacNeil Laboratory
McMaster University
Department of Biochemistry and Biomedical Sciences
Publications
SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest M Di Bernardo, VL León Guerrero, JC Sutoski, WR Hardy, LT MacNeil
Genetics, 2024
Jiang Y, MacNeil LT. Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies. Molecular Neurodegeneration 18(1):82. 2023
Cook MA, Pallant D, Ejim L, Sutherland AD, Wang X, Johnson JW, McCusker S, Chen X, George M, Chou S, Koteva K, Wang W, Hobson C, Hackenberger D, Waglechner N, Ejim O, Campbell T, Medina R, MacNeil LT, Wright GD. Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory. Journal of Industrial Microbiology and Biotechnology Dec 05, 2023.
Wang L, Chou S, Wright G, MacNeil L, Moradi M. “Supervised and semi-supervised methods of nematode images classification for drug discovery”, SPIE Medical Imaging 2024.
Hyperpiliation reduces Pseudomonas aeruginosa pathogenicity by impeding type III secretion
SLN Kilmury, KJ Graham, RP Lamers, LT MacNeil, LL Burrows
bioRxiv, 2021.01. 28.428742
MacNeil LT, Schertzer JD, Steinberg GR. (2020) Bacteria transmit metformin-associated lifespan extension. Nature Reviews Endocrinology 16(1),9-10.
Mesbahi H, Pho KB, Tench A, Leon Guerrero V, MacNeil LT. (2020) C. elegans ELT-3 regulates cuticle collagen expression in response to environmental stimuli. Genetics 215:483-495.
Rashid S, Pho KB, Mesbahi H, MacNeil LT. (2020) Nutrient sensing and response drive developmental progression in Caenorhabditis elegans. BioEssays. https://doi.org/10.1002/bies.201900194
Pho KB, MacNeil LT. (2019) Biology is the root of variability: cautionary tales in Caenorhabditis elegans biology. Biochemical Society Transactions 47(3):BST20190001.
Vera-Cruz AG, Amon S, Rashid A, MacNeil LT. (2018). wrt-2 expression oscillates during larval development. microPublication: biology. https://doi.org/10.17912/4BW7-EP56.
Hu Q, D’Amora DR, MacNeil LT, Walhout AJM, Kubiseski TJ. (2018). The Caenorhabditis elegans oxidative stress response requires the NHR-49 transcription factor. G3 8:3857-3863.
Marko VA, Kilmurry SLN, MacNeil LT, Burrows LL. (2018). Pseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity. PLoS Pathog. 18;14(5):e1007074.
Yan, A, Culp E, Perry J, Lau JT, MacNeil LT, Surette MG, Wright GD. (2018). Transformation of the anticancer drug doxorubicin in the human microbiome. ACS Infect Dis 4(1):68-76.
Hu Q, D’Amora DR, MacNeil LT, Walhout AJM, Kubiseski TJ. (2017). The GATA transcription factor ELT-3 is required for SKN-1/Nrf2 dependent oxidative stress response in C. elegans. Genetics 206(4):1909-1922.
Rashid, S, MacNeil LT. (2017). Packing on the pounds in response to bacterial growth conditions. Dev. Cell. 41(4):335-336.
Leulier F, MacNeil LT, Lee WJ, Rawls JF, Cani PD, Schwarzer M, Zhao L, Simpson SJ. (2017). Integrative Physiology: At the crossroads of nutrition, microbiota, animal physiology and human health. Cell Metabolism. 25(3):522-534.
MacNeil, LT, Pons, C, Arda, HE, Giese, GE, Myers, CL, Walhout, AJM. (2015). Transcription factor activity mapping of a tissue-specific in vivo gene regulatory network . Cell Systems 2:152-162.
Conte, D Jr., MacNeil, LT, Walhout, AJM, and Mello, CC. (2015). RNA Interference in Caenorhabditis elegans. Curr. Protoc. Mol. Biol. 109:26.3.1-26.3.30.
Watson, E, MacNeil, LT, Ritter, AD, Yilmaz, LS, Rosebrock, AP, Caudy, AA, Walhout, AJM. (2014). Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits. Cell 156:759-70.
MacNeil LT, Watson E, Arda HE, Zhu LJ, Walhout AJM. (2013). Diet-induced developmental acceleration independent of TOR and insulin in C. elegans. Cell 153:240-252.
Faculty of 1000 recommended
*Watson E, *MacNeil LT, Arda HE, Zhu LJ, Walhout AJM. (2013). Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response. Cell 153:253-266.
*Equal contribution
MacNeil LT, Walhout AJM. (2013). Food, pathogen, signal: the multifaceted nature of a bacterial diet. Worm 2:4, e26454.
MacNeil LT, Walhout AJM. (2011). Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression. Genome Res. 21:645-57.
Arda HE, Taubert S, MacNeil LT, Conine CC, Tsuda B, Van Gilst M, Sequerra R, Doucette-Stamm L, Yamamoto KR, Walhout AJM. (2010). Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Mol. Sys. Biol. 6:367.
Gumienny TL, MacNeil L, Zimmerman CM, Wang H, Chin L, Wrana JL, Padgett, RW. (2010). Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling. PloS Genetics 6: e1000963.
MacNeil LT, Hardy WR, Pawson AJ, Wrana JL, Culotti JG. (2009). UNC-129 alters the response to UNC-6/Netrin by regulating the decision between UNC-40 dependent and independent UNC-5 signaling. Nature Neuroscience 12:150-5.
Kurpios N, MacNeil LT, Shepherd TG, Hassell JA. (2009). PEA3 ets gene functions during morphogenesis and stem cell differentiation in the mouse mammary gland. Dev. Biol. 325:106-21.
Gumienny TL, MacNeil LT, Wang H, de Bono M, Wrana, JL, Padgett, RW. (2007). Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Current Biol. 17, 159-64.