Publications | macneillab

Publications from the MacNeil Lab

Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi

Xuefei Chen, H Diessel Duan, Michael J Hoy, Kalinka Koteva, Michaela Spitzer, Allison K Guitor, Emily Puumala, Aline A Fiebig, Guanggan Hu, Bonnie Yiu, Sommer Chou, Zhuyun Bian, Yeseul Choi, Amelia Bing Ya Guo, Wenliang Wang, Sheng Sun, Nicole Robbins, Anna Floyd Averette, Michael A Cook, Ray Truant, Lesley T MacNeil, Eric D Brown, James W Kronstad, Brian K Coombes, Leah E Cowen, Joseph Heitman, Huilin Li, Gerard D Wright

Cell. 2026 Jan 22;189(2):620-639.e28. doi: 10.1016/j.cell.2025.11.036. Epub 2025 Dec 31. PMID: 41478284; PMCID: PMC12774453.

Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson’s disease.

Ngana GS, Di Bernardo MA, Surette MG, MacNeil LT.

Mech Ageing Dev. 2025 Jun;225:112061. doi: 10.1016/j.mad.2025.112061. Epub 2025 Apr 19. PMID: 40258426.

Twists and turns in the story of learned avoidance

Lesley T MacNeil

Elife. 2025 Nov 11;14:e109427. doi: 10.7554/eLife.109427. PMID: 41217810; PMCID: PMC12604852.

Temperate phages increase antibiotic effectiveness in a Caenorhabditis elegans infection model

Rabia Fatima, Gayatri Nair, Jordan Mayol, Lesley T MacNeil, Alexander P Hynes

mBio 16:e01621-25.
https://doi.org/10.1128/mbio.01621-25

Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library

Chen X, Koteva K, Chou S, Guitor A, Pallant D, Lee Y, Sychantha D, French S, Hackenberger D, Robbins N, Cook M, Brown ED, MacNeil LT, Cowen L, Wright G.

Nat Commun. 2025 Aug 8;16(1):7337. doi: 10.1038/s41467-025-62630-z. PMID: 40781075; PMCID: PMC12334575.

Hyperpiliation, not loss of pilus retraction, reduces Pseudomonas aeruginosa pathogenicity

Sara LN Kilmury, Katherine J Graham, Ryan P Lamers, Lesley T MacNeil, Lori L Burrows

Microbiol Spectr. 2025 Apr;13(4):e0255824. doi: 10.1128/spectrum.02558-24. Epub 2025 Feb 25. PMID: 39998244; PMCID: PMC11960060.

Self-supervised Learning for Drug Discovery Using Nematode Images: Method and Dataset

Lyuyang Wang, Sommer Chou, Mehrdad Eshraghi Dehaghani, Gerry Wright, Lesley MacNeil, Mehdi Moradi

IEEE J Biomed Health Inform. 2025 Jul;29(7):5123-5132. doi: 10.1109/JBHI.2025.3546603. PMID: 40031549.

SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest

M Di Bernardo, VL León Guerrero, JC Sutoski, WR Hardy, LT MacNeil

Genetics. 2024 Oct 7;228(2):iyae093. doi: 10.1093/genetics/iyae093. PMID: 38861412; PMCID: PMC11630764.

C. elegans MAPS the way: the 2022 C. elegans meeting on metabolism, aging, pathogenesis, and stress (MAPS 2022)

Yuwei Jiang, Lesley T MacNeil

Front Physiol. 2023 Nov 13;14:1331912. doi: 10.3389/fphys.2023.1331912. PMID: 38033339; PMCID: PMC10682946.

A33 EFFECTS OF THE NEXT GENERATION PROBIOTIC, AKKERMANSIA MUCINIPHILA, ON INTESTINAL INFLAMMATION AND BARRIER FUNCTION

J Grondin, H Wang, S Haq, YH Kwon, L MacNeil, M Surette, W Khan

J Can Assoc Gastroenterol. 2023 Mar 7;6(Suppl 1):18. doi: 10.1093/jcag/gwac036.033. PMCID: PMC9991313.

Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory.

Cook MA, Pallant D, Ejim L, Sutherland AD, Wang X, Johnson JW, McCusker S, Chen X, George M, Chou S, Koteva K, Wang W, Hobson C, Hackenberger D, Waglechner N, Ejim O, Campbell T, Medina R, MacNeil LT, Wright GD.

J Ind Microbiol Biotechnol. 2023 Feb 17;50(1):kuad042. doi: 10.1093/jimb/kuad042. PMID: 38052426; PMCID: PMC10724011.

Microbiomes: How a gut bacterium promotes healthier living in a nematode

Lesley T MacNeil

Curr Biol. 2022 May 9;32(9):R428-R430. doi: 10.1016/j.cub.2022.04.008. PMID: 35537396.

Cuticle Collagen Expression Is Regulated in Response to Environmental Stimuli by the GATA Transcription Factor ELT-3 in Caenorhabditis elegans

Hiva Mesbahi, Kim B Pho, Andrea J Tench, Victoria L Leon Guerrero, Lesley T MacNeil

Genetics. 2020 Jun;215(2):483-495. doi: 10.1534/genetics.120.303125. Epub 2020 Mar 30. PMID: 32229533; PMCID: PMC7268988.

Nutrient Sensing and Response Drive Developmental Progression in Caenorhabditis elegans

Sabih Rashid, Kim B Pho, Hiva Mesbahi, Lesley T MacNeil

Bioessays. 2020 Mar;42(3):e1900194. doi: 10.1002/bies.201900194. Epub 2020 Jan 31. PMID: 32003906.

Bacteria transmit metformin-associated lifespan extension

MacNeil LT, Schertzer JD, Steinberg GR.

Nat Rev Endocrinol. 2020 Jan;16(1):9-10. doi: 10.1038/s41574-019-0278-3. PMID: 31645681.

Biology is the root of variability: cautionary tales in Caenorhabditis elegans biology.

Pho KB, MacNeil LT

Biochem Soc Trans. 2019 Jun 28;47(3):887-896. doi: 10.1042/BST20190001. Epub 2019 May 24. PMID: 31127069.

The Caenorhabditis elegans oxidative stress response requires the NHR-49 transcription factor

Hu Q, D’Amora DR, MacNeil LT, Walhout AJM, Kubiseski TJ.

G3 (Bethesda). 2018 Dec 10;8(12):3857-3863. doi: 10.1534/g3.118.200727. PMID: 30297383; PMCID: PMC6288832.

Pseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity.

Marko VA, Kilmurry SLN, MacNeil LT, Burrows LL.

2018 May 18;14(5):e1007074. doi: 10.1371/journal.ppat.1007074. PMID: 29775484; PMCID: PMC5979040.

Transformation of the anticancer drug doxorubicin in the human microbiome.

Yan, A, Culp E, Perry J, Lau JT, MacNeil LT, Surette MG, Wright GD.

ACS Infect Dis. 2018 Jan 12;4(1):68-76. doi: 10.1021/acsinfecdis.7b00166. Epub 2017 Nov 30. PMID: 29160065.

wrt-2 expression oscillates during larval development.

Vera-Cruz AG, Amon S, Rashid A, MacNeil LT.

MicroPubl Biol. 2018 Oct 11;2018:10.17912/4bw7-ep56. doi: 10.17912/4bw7-ep56. PMID: 32550385; PMCID: PMC7282508.

The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2

Queenie Hu, Dayana R D’Amora, Lesley T MacNeil, Albertha JM Walhout, Terrance J Kubiseski

Genetics. 2017 Aug;206(4):1909-1922. doi: 10.1534/genetics.116.198788. Epub 2017 Jun 9. PMID: 28600327; PMCID: PMC5560797.

Packing on the pounds in response to bacterial growth conditions

Rashid, S, MacNeil LT.

Dev Cell. 2017 May 22;41(4):335-336. doi: 10.1016/j.devcel.2017.05.010. PMID: 28535369.

Integrative Physiology: At the crossroads of nutrition, microbiota, animal physiology and human health.

Leulier F, MacNeil LT, Lee WJ, Rawls JF, Cani PD, Schwarzer M, Zhao L, Simpson SJ.

Cell Metab. 2017 Mar 7;25(3):522-534. doi: 10.1016/j.cmet.2017.02.001. PMID: 28273475; PMCID: PMC6200423.

Transcription factor activity mapping of a tissue-specific in vivo gene regulatory network .

MacNeil, LT, Pons, C, Arda, HE, Giese, GE, Myers, CL, Walhout, AJM.

Cell Syst. 2015 Aug 26;1(2):152-162. doi: 10.1016/j.cels.2015.08.003. PMID: 26430702; PMCID: PMC4584425.

RNA Interference in Caenorhabditis elegans.

Conte, D Jr., MacNeil, LT, Walhout, AJM, and Mello, CC.

Curr Protoc Mol Biol. 2015 Jan 5;109:26.3.1-26.3.30. doi: 10.1002/0471142727.mb2603s109. PMID: 25559107; PMCID: PMC5396541.

Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits.

Watson, E, MacNeil, LT, Ritter, AD, Yilmaz, LS, Rosebrock, AP, Caudy, AA, Walhout, AJM.

Cell. 2014 Feb 13;156(4):759-70. doi: 10.1016/j.cell.2014.01.047. Erratum in: Cell. 2014 Mar 13;156(6):1336-7. PMID: 24529378; PMCID: PMC4169190.

Food, pathogen, signal: the multifaceted nature of a bacterial diet.

MacNeil LT, Walhout AJM.

Worm. 2013 Oct 1;2(4):e26454. doi: 10.4161/worm.26454. Epub 2013 Sep 30. PMID: 24744980; PMCID: PMC3917966.

Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response.

*Watson E, *MacNeil LT, Arda HE, Zhu LJ, Walhout AJM.

*Equal contribution

Cell, Volume 153, Issue 1, 2013, Pages 253-266, ISSN 0092-8674,
https://doi.org/10.1016/j.cell.2013.02.050.

Diet-induced developmental acceleration independent of TOR and insulin in C. elegans.

MacNeil LT, Watson E, Arda HE, Zhu LJ, Walhout AJM.

Cell. 2013 Mar 28;153(1):240-52. doi: 10.1016/j.cell.2013.02.049. PMID: 23540701; PMCID: PMC3821073.

Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression.

MacNeil LT, Walhout AJM.

Genome Res. 2011 May;21(5):645-57. doi: 10.1101/gr.097378.109. Epub 2011 Feb 4. Erratum in: Genome Res. 2011 Jun;21(6):999. PMID: 21324878; PMCID: PMC3083081.

Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response

Renan P Souza, Marco A Romano-Silva, Jeffrey A Lieberman, Herb

J Psychiatr Res. 2010 Aug;44(11):700-6. doi: 10.1016/j.jpsychires.2010.01.002. Epub 2010 Jan 29. PMID: 20116071.

Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling.

Gumienny TL, MacNeil L, Zimmerman CM, Wang H, Chin L, Wrana JL, Padgett, RW.

PLoS Genet. 2010 May 20;6(5):e1000963. doi: 10.1371/journal.pgen.1000963. PMID: 20502686; PMCID: PMC2873917.

Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network.

Arda HE, Taubert S, MacNeil LT, Conine CC, Tsuda B, Van Gilst M, Sequerra R, Doucette-Stamm L, Yamamoto KR, Walhout AJM.

Mol Syst Biol. 2010 May 11;6:367. doi: 10.1038/msb.2010.23. PMID: 20461074; PMCID: PMC2890327.

Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

Benson C Lu, Cristina Cebrian, Xuan Chi, Satu Kuure, Richard Kuo, Carlton M Bates, Silvia Arber, John Hassell, Lesley MacNeil, Masato Hoshi, Sanjay Jain, Naoya Asai, Masahide Takahashi, Kai M Schmidt-Ott, Jonathan Barasch, Vivette D'Agati, Frank Costantini

Nat Genet. 2009 Dec;41(12):1295-302. doi: 10.1038/ng.476. Epub 2009 Nov 8. Erratum in: Nat Genet. 2010 Apr;42(4):361. PMID: 19898483; PMCID: PMC2787691.

UNC-129 alters the response to UNC-6/Netrin by regulating the decision between UNC-40 dependent and independent UNC-5 signaling.

MacNeil LT, Hardy WR, Pawson AJ, Wrana JL, Culotti JG.

Nat Neurosci. 2009 Feb;12(2):150-5. doi: 10.1038/nn.2256. Epub 2009 Jan 25. PMID: 19169249; PMCID: PMC2745997.

The PEA3 ets gene functions during morphogenesis and stem cell differentiation in the mouse mammary gland.

Kurpios N, MacNeil LT, Shepherd TG, Hassell JA.

Dev Biol. 2009 Jan 1;325(1):106-21. doi: 10.1016/j.ydbio.2008.09.033. Epub 2008 Oct 18. PMID: 18977342.

Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans.

Gumienny TL, MacNeil LT, Wang H, de Bono M, Wrana, JL, Padgett, RW.

Curr Biol. 2007 Jan 23;17(2):159-64. doi: 10.1016/j.cub.2006.11.065. PMID: 17240342.